AD-affiliated genes

List of the 499 genes found to be associated with Alzheimer's disease in the MalaCards database. The following description is taken directly from the database. The genes list is composed by taking into account: i) The GeneCards search mechanism, ii) Genetic testing resources supplying specific genetic tests for the disease, iii) Genetic variations resources supplying specific causative variations in genes for the disease and iv) Resources that manually curate the association of the disease with genes. A prioritizing algorithm is applied to generate the genes list. The table shows gene symbols, descriptions, relevance scores, and the context according to which the gene is related to the disease. The relevance score is computed by factoring the importance of the different resources associating the gene with the disease.MalaCards "elite" genes (marked with *) are those likely to be associated with causing the disease, since their gene-disease associations are supported by manually curated and trustworthy sources.

本数据集收录了MalaCards数据库中被证实与阿尔茨海默病（Alzheimer's disease）相关的499个基因，以下描述直接取自该数据库。该基因列表的构建综合考量了以下四方面内容：i）GeneCards搜索机制；ii）为该疾病提供专属基因检测的遗传检测资源；iii）收录该疾病相关基因特异性致病变异的遗传变异资源；iv）手动进行基因-疾病关联注释（curate）的资源。采用优先级排序算法生成该基因列表。该表格展示了基因符号、基因描述、关联评分以及该基因与疾病关联的相关背景。关联评分通过综合考量不同关联资源的重要性权重计算得出。MalaCards数据库的“精英”（elite）基因（以*标记）为极有可能参与疾病致病过程的基因，因其基因-疾病关联关系得到了经人工注释且可靠的来源支持。