Data_Sheet_2_Agreement of Magnetic Resonance Imaging With Computed Tomography in the Assessment for Acute Skull Fractures in a Canine and Feline Cadaver Model.xlsx

Computed tomography (CT) is the imaging modality of choice to evaluate patients with acute head trauma. However, magnetic resonance imaging (MRI) may be chosen in select cases. The objectives of this study were to evaluate the agreement of MRI with CT in the assessment for presence or absence of acute skull fractures in a canine and feline cadaver model, compare seven different MRI sequences (T1-W, T2-W, T2-FLAIR, PD-W, T2*-W, “SPACE” and “VIBE”), and determine agreement of four different MRI readers with CT data. Pre- and post-trauma CT and MRI studies were performed on 10 canine and 10 feline cadaver heads. Agreement of MRI with CT as to presence or absence of a fracture was determined for 26 individual osseous structures and four anatomic regions (cranium, face, skull base, temporomandibular joint). Overall, there was 93.5% agreement in assessing a fracture as present or absent between MRI and CT, with a significant difference between the pre and post trauma studies (99.4 vs. 87.6%; p < 0.0001; OR 0.042; 95% CI 0.034–0.052). There was no significant difference between dogs and cats. The agreement for the different MRI sequences with CT ranged from 92.6% (T2*-W) to 94.4% (PD-W). There was higher agreement of MRI with CT in the evaluation for fractures of the face than other anatomic regions. Agreement with CT for individual MRI readers ranged from 92.6 to 94.7%. A PD-W sequence should be added to the MR protocol when evaluating the small animal head trauma patient.

计算机断层扫描（Computed Tomography，CT）是评估急性颅脑创伤患者的首选成像手段。不过在特定病例中，可选择磁共振成像（Magnetic Resonance Imaging，MRI）进行评估。本研究的目的为：在犬猫尸体模型中评估MRI与CT在急性颅骨骨折存在与否评估中的一致性；对比7种不同MRI序列（T1加权成像（T1-W）、T2加权成像（T2-W）、T2液体衰减反转恢复成像（T2-FLAIR）、质子密度加权成像（PD-W）、T2*加权成像（T2*-W）、"SPACE"序列及"VIBE"序列）；明确4名不同MRI阅片者与CT数据间的评估一致性。研究对10只犬及10只猫的尸体头颅分别开展创伤前与创伤后的CT及MRI检查。针对26个独立骨结构与4个解剖区域（颅骨、面颅、颅底、颞下颌关节）的骨折存在与否，计算MRI与CT的评估一致性。总体而言，MRI与CT在判断骨折存在与否时的一致性达93.5%，创伤前与创伤后检查结果间存在显著差异（99.4% vs. 87.6%；p < 0.0001；比值比（OR）0.042；95%置信区间（CI）0.034–0.052）。犬与猫之间的评估结果无显著差异。不同MRI序列与CT的一致性范围为92.6%（T2*-W）至94.4%（PD-W）。MRI与CT在面颅骨折评估中的一致性高于其余解剖区域。4名不同MRI阅片者与CT数据的评估一致性范围为92.6%至94.7%。评估小动物颅脑创伤患者时，应将质子密度加权成像（PD-W）序列纳入MRI检查方案。