Loci with significant interaction between fish oil supplementation and blood lipid levels.

Listed variants represent the lead association within a 1 Mb region for 1df tests of variant × fish oil interaction after meta-analysis. The name of the nearest gene is listed with each lead variant. Bold P-values indicate meeting the genome-wide significance threshold of P −8. Main effect P-values are calculated using Stage 1 (UK Biobank) participants only, and without interaction (Eq (2); stratified for exposure groups as in Eq (3)). Effect, beta coefficient of the minor allele dose term (βG in Eq (1)); MAF, minor allele frequency; SE, standard error; Int effect, beta coefficient of the interaction term (βG×EG×E in Eq (1)). Lipid traits were measured in mmol/L.

本列表收录的变异为荟萃分析完成后，针对「变异×鱼油交互作用」开展单自由度检验时，1 Mb区域内的先导关联信号。每个先导变异均附带其最近的基因名称。其中加粗的P值代表该关联达到全基因组显著性阈值（P<1×10^-8）。主效应P值仅通过第一阶段（英国生物库（UK Biobank））的参与者数据计算得到，且未纳入交互作用项（公式(2)；按公式(3)的方法按暴露组进行分层）。各字段定义如下：Effect为次要等位基因剂量项的β系数（对应公式(1)中的β_G）；MAF为次要等位基因频率（minor allele frequency）；SE为标准误（standard error）；Int effect为交互作用项的β系数（对应公式(1)中的βG×EG×E）。脂质性状的测量单位为毫摩尔每升（mmol/L）。