Genome-wide microRNA expression profiles of rat hippocampus in a chronic temporal lobe epilepsy model induced by amygdala stimulation

MicroRNAs (miRNAs) have been found to participate in the pathogenesis of several neurological diseases including epilepsy. To date, the expression and functions of miRNAs in chronic temporal lobe epilepsy (TLE), the most common type of refractory epilepsy in adults, have not been well characterized. Here, we adopted high-throughput sequencing to investigate miRNA expression profile in a chronic TLE model induced by amygdala stimulation微小RNA（MicroRNAs，miRNAs）已被证实参与包括癫痫在内的多种神经系统疾病的发病进程。截至目前，针对成人最常见的难治性癫痫类型——慢性颞叶癫痫（TLE）中miRNA的表达与功能，相关研究尚未得到充分阐释。本研究采用高通量测序技术，对杏仁核刺激诱导的慢性TLE模型中的miRNA表达谱展开了探究。