Additional file 3 of Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis

Additional file 3: Supplementary Data S1. 4794 differentially methylated positions (DMPs) identified associated with ankylosing spondylitis in the discovery cohort. Supplementary Data S2. 1,048 differentially variable positions (DVPs) identified with iEVORA algorithm in the discovery cohort. Supplementary Data S3. 4,144 differentially expressed genes (DEGs) identified associated with ankylosing spondylitis in the discovery cohort. Supplementary Data S4. 158 differentially methylated positions (DMPs) identified to be correlated with the corresponding mRNA expression levels of 112 genes in Pearson correlation analyses. Supplementary Data S5. The differentially methylated positions (DMPs) of 6 key genes identified in the Pearson correlation analyses were verified in the validation cohort.

附加文件3：补充数据S1：在发现队列（discovery cohort）中鉴定得到4794个与强直性脊柱炎（ankylosing spondylitis）相关的差异甲基化位点（differentially methylated positions, DMPs）。补充数据S2：在发现队列中通过iEVORA算法鉴定得到1048个差异可变位点（differentially variable positions, DVPs）。补充数据S3：在发现队列中鉴定得到4144个与强直性脊柱炎相关的差异表达基因（differentially expressed genes, DEGs）。补充数据S4：经Pearson相关分析（Pearson correlation analyses）鉴定得到158个差异甲基化位点，这些位点与112个基因的对应mRNA表达水平存在相关性。补充数据S5：在验证队列（validation cohort）中，对Pearson相关分析中鉴定出的6个关键基因的差异甲基化位点进行了验证。