Dental development

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic pathways leading to normal and abnormal growth, development and health. An important focus of Generation R is to identify early life determinants of common (mostly non-communicable) diseases in adulthood. Pregnant women living in the Rotterdam area, the Netherlands, were included between 2002 and 2006. After birth, the children and their parents have been followed in multiple assessment waves up until young adulthood.

Generation R研究是一项基于人群的前瞻性队列研究，随访对象从胎儿期直至成年期。该研究旨在识别导致正常与异常生长、发育及健康状况的早期环境与遗传通路。Generation R研究的一个重要关注点是识别成年期常见（多为非传染性）疾病的生命早期决定因素。2002年至2006年间，研究纳入了居住在荷兰鹿特丹地区的孕妇。出生后，儿童及其父母通过多轮评估接受随访，直至青年期。