Expression data from the visceral adipose tissues of Lgr4 mutant (KO) and wild-type (WT) mice. Expression data from the visceral adipose tissues of Lgr4 mutant (KO) and wild-type (WT) mice

Lgr4 acts as a key factor to regulate energy expenditure and body weight. Visceral fat (epidydimal white adipose tissue, eWAT) show a significant reduction in Lgr4 mutant mice than littermate controls, especially in high-fat diet (HFD) condition. A white-to-brown fat switch of eWAT in Lgr4 mice was reported by our group. However, the whole-genome expression profile of eWAT has not been comphrehensively studied. We used microarrays to reveal the potential novel factors underlying browning process. Overall design: eWAT tissues from both Lgr4 mutant and WT mice under chow diet and HFD diet were sampled for RNA extraction and hybridization on Affymetrix microarrays.