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Bacterial pneumonia poses a global health threat, worsened by drug-resistant bacteria, underscoring the urgent need for new antimicrobial agents. Antimicrobial peptides show promising broad-spectrum activity and low resistance development. This study reports a linear antimicrobial peptide 1003 consisting of four repeating units of (D-tryptophan)-(D-arginine)-(D-lysine). It exhibits high stability and strong antimicrobial activity against multidrug-resistant bacteria like methicillin-resistant Staphylococcus aureus and Klebsiella pneumoniae, with improved biocompatibility.

细菌性肺炎（Bacterial pneumonia）是全球性公共健康威胁，耐药细菌的存在进一步加剧了这一危机，凸显了开发新型抗菌剂的迫切需求。抗菌肽（Antimicrobial peptides）展现出优异的广谱抗菌活性，且不易诱发细菌耐药性。本研究报道了一种由(D-色氨酸)-(D-精氨酸)-(D-赖氨酸)四重复单元构成的线性抗菌肽1003，该肽不仅稳定性优异，还对耐甲氧西林金黄色葡萄球菌（methicillin-resistant Staphylococcus aureus）、肺炎克雷伯菌（Klebsiella pneumoniae）等多重耐药细菌具有强效抗菌活性，同时生物相容性得到显著提升。