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Transcriptome analysis in Nrdc-deficient MEF using RNA-seq

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90108
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Nardilysin (Nrdc) is a metallopeptidase of M16 family, which has been recently identified as a transcriptional coregulator. Here, we characterize the role of Nrdc in transcriptional regulation by genome-wide analysis using ChIP-seq and transcriptome. Gene expression profiles were examined by RNA-seq in immortalized mouse embryonic fibroblasts (MEF). MEFs generated from wild-type (+/+) and Nrdc-deficient (-/-) mice were used. MEF-/- cells, in which Nrdc was reintroduced by lenti-virus vector, were also used as control.
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2019-07-09
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