Deciphering the causal relationship between blood pressure and regional white matter integrity: a two-sample Mendelian randomization study

Table S1. A list of 39 regional white matter (WM) integrity measured by fractional antitropy (FA). Table S2. Self-report neurological characteristics of UK Biobank's participants from two independent association sample sets for the two-sample Mendelian randomization (MR) analysis. Table S3. Numbers of candidate instrumental variables (IVs) determined at each step of our statistical method by separately using UK Biobank (UKB) GWAS and existing meta-analyzed GWAS. Table S4. Gene annotations for determined valid instrumental variables (IVs) carried into the two-sample Mendelian Randomization (MR) analysis by separately using UK Biobank (UKB) GWAS and existing meta-analyzed GWAS. Table S5. Results of association analysis and Mendelian Randomization analysis (implemented with generalized version of inverse-variance weighted (gen-IVW) approach) in the study samples. Table S6. Results of alternative Mendelian randomization (MR) approach and sensitivity analyses by using data from UK Biobank (UKB) cohort. Table S7. Results of adaptively weighted (AW) Fisher's method and mendelian randomization analysis implemented with a generalized version of inverse-variance weights method (gen-IVW) Table S8. Results and numbers of candidate instrumental variables (IVs) in each step of our two reverse two-sample Mendelian Randomization (MR) analyses using UK Biobank (UKB) cohort. Supplmentary File. Results of leave-one-out analyses STROBE-MR checklist. STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME) checklist

表S1 39项区域脑白质（white matter, WM）完整性指标，以各向异性分数（fractional anisotropy, FA）表征。表S2 针对两样本孟德尔随机化（Mendelian randomization, MR）分析的两个独立关联样本集，英国生物银行（UK Biobank）参与者的自我报告神经学特征。表S3 本研究统计方法各步骤中，分别使用英国生物银行（UK Biobank, UKB）全基因组关联分析（Genome-Wide Association Study, GWAS）与已发表的荟萃分析全基因组关联分析数据集，所筛选得到的候选工具变量（instrumental variables, IVs）的数量。表S4 分别使用英国生物银行（UK Biobank, UKB）全基因组关联分析与已发表的荟萃分析全基因组关联分析数据集，纳入两样本孟德尔随机化分析的有效工具变量的基因注释信息。表S5 本研究样本中关联分析与孟德尔随机化分析（采用广义逆方差加权（generalized inverse-variance weighted, gen-IVW）方法实施）的结果。表S6 基于英国生物银行（UK Biobank, UKB）队列数据，采用替代孟德尔随机化方法与敏感性分析得到的结果。表S7 自适应加权（adaptively weighted, AW）Fisher检验法结果，以及采用广义逆方差加权（generalized inverse-variance weighted, gen-IVW）方法实施的孟德尔随机化分析结果。表S8 采用英国生物银行（UK Biobank, UKB）队列数据开展的两项反向两样本孟德尔随机化分析各步骤中的候选工具变量数量与分析结果。补充文件：留一法分析结果、STROBE-MR核查清单、加强流行病学观察性研究报告-分子流行病学（Strengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology, STROBE-ME）核查清单