Modification of gut microbiota in the treatment of insulin resistance

The performance of the altered gut microbiota is suspected to contribute to the onset and progression of type 2 diabetes (T2D). We hypothesized that (i) the complex gut microbiome and metabolome (MIME) composition differs in lean healthy (LH, obese healthy (OB) and obese diabetic drug-naive T2D subjects (DM); (ii) the effects of inulin on glucose tolerance and insulin sensitivity is, at least partly, explained by the response of gut microbiota to the inulin intervention