UNKNOWN PRIMARY TUMOR SITES IN SPINAL METASTASIS

ABSTRACT Objective: The goal of the study was to report the prevalence of spinal metastasis with unknown primary tumor, clinical features, treatment results and patient survival. Methods: A retrospective evaluation of 103 patients with spinal metastasis and epidural compression, who underwent surgical treatment between March 2009 and August 2015. The prevalence of metastatic spinal tumor with unknown primary tumor was evaluated, as well clinical features, survival and treatment results. Results: Of 103 patients with spinal metastasis and epidural compression, seven patients (6.8%) with unknown primary tumor site were identified; five (71.4%) male and two (28.6%) female, with ages ranging from 37 to 67 years (50.7 years). The metastasis was located in the thoracic spine in six of the patients (85.7%) and in the cervical spine in one (14.3%). The mean survival time was 44.8 days. Conclusion: Spinal metastasis with unknown primary tumor was found in 6.8% of patients. The prognosis and outcomes were poor, and patients had poor survival rates. Level of evidence III; Experimental study.

摘要
目的：本研究旨在报告原发灶不明脊柱转移瘤的患病率、临床特征、治疗效果及患者生存情况。
方法：本研究回顾性分析了2009年3月至2015年8月期间接受手术治疗的103例脊柱转移伴硬膜外受压患者，评估了原发灶不明脊柱转移瘤的患病率、临床特征、生存情况及治疗效果。
结果：在103例脊柱转移伴硬膜外受压患者中，共确认7例（6.8%）原发灶不明的患者；其中男性5例（71.4%）、女性2例（28.6%），年龄范围为37至67岁，平均年龄50.7岁。6例患者（85.7%）的转移灶位于胸椎，1例（14.3%）位于颈椎，患者平均生存时间为44.8天。
结论：原发灶不明的脊柱转移瘤占本次研究患者的6.8%，该类患者预后及转归较差，生存率偏低。本研究证据等级为III级，属于实验性研究。