Heart rate variability in children with type 1 diabetes mellitus

OBJECTIVE:To gather current information about the effects of type 1 diabetes mellitus on children's cardiac autonomic behavior.DATA SOURCES: The search of articles was conducted on PubMed, Ibecs, Medline, Cochrane, Lilacs, SciELO and PEDro databases using the MeSH terms: "autonomic nervous system", "diabetes mellitus", "child", "type 1 diabetes mellitus", "sympathetic nervous system" and "parasympathetic nervous system", and their respective versions in Portuguese (DeCS). Articles published from January 2003 to February 2013 that enrolled children with 9-12 years old with type 1 diabetes mellitus were included in the review.DATA SYNTHESIS: The electronic search resulted in four articles that approached the heart rate variability in children with type 1 diabetes mellitus, showing that, in general, these children present decreased global heart rate variability and vagal activity. The practice of physical activity promoted benefits for these individuals.CONCLUSIONS: Children with type 1 diabetes mellitus present changes on autonomic modulation, indicating the need for early attention to avoid future complications in this group.

**研究目标**：系统收集1型糖尿病对儿童心脏自主神经功能影响的最新研究数据。
**数据来源**：本研究检索了PubMed、Ibecs、Medline、Cochrane、Lilacs、SciELO及PEDro数据库，检索采用医学主题词（MeSH，Medical Subject Headings）："自主神经系统"、"糖尿病"、"儿童"、"1型糖尿病"、"交感神经系统"、"副交感神经系统"，以及其对应的葡萄牙语术语（DeCS，Descritores em Ciências da Saúde）。本综述最终纳入2003年1月至2013年2月期间发表的、针对9~12岁1型糖尿病儿童的相关研究文章。
**数据综合分析**：本次电子检索共获取4篇探讨1型糖尿病儿童心率变异性的研究文献，结果显示，此类儿童整体心率变异性与迷走神经活动普遍降低；规律的体育锻炼可对此类人群产生积极获益。
**研究结论**：1型糖尿病儿童存在自主神经调节功能异常，提示需尽早开展针对性干预，以避免该群体未来出现相关并发症。