Additional file 13: Table S12. of DNA methylation analysis of paediatric low-grade astrocytomas identifies a tumour-specific hypomethylation signature in pilocytic astrocytomas

Comparison of methylation and expression for genes associated with 315 differentially methylated sites in pilocytic and diffuse astrocytomas. Correlation coefficients are shown for differentially methylated CpG sites that show a difference of â Ľ2-fold in expression of the associated gene. Expression probes were only assessed if they were located within the mRNA transcript. A) CpG sites located within the promoter of the gene. B) CpG sites located within the gene body, 3â UTR and intergenic regions. As the CpG is not within a promoter, correlation was also calculated for a CpG site within the promoter (where possible within the TSS200; brown panel). For each correlation p-values and Benjamini-Hochberg corrected p-values are shown. The table is ordered by FDR-corrected p-values (sites with a p-value <0.05 are shown in blue). Positive correlation is highlighted in yellow. Up-regulated genes in diffuse astrocytomas are highlighted in green. When the expression probe was located in an exon, the probe for the full transcript was used for the correlation (indicated by the asterisk). (XLSX 85 kb)

本数据集针对毛细胞型星形细胞瘤与弥漫型星形细胞瘤中315个差异甲基化位点的相关基因，开展甲基化水平与基因表达水平的对比分析。针对关联基因表达量差异达2倍及以上的差异甲基化CpG位点，给出了其相关系数。仅当表达探针位于mRNA转录本范围内时，才会对其进行评估。
A）位于基因启动子区域内的CpG位点；B）位于基因本体、3'非翻译区（3' UTR）以及基因间区域的CpG位点。由于目标CpG位点不在启动子区域内，本分析同时计算了该基因启动子区域内（若可行则位于转录起始位点上游200bp区域（TSS200），即棕色面板）的CpG位点的相关系数。
针对每一组相关性分析，均给出了原始p值与经Benjamini-Hochberg校正后的p值。本表格按经错误发现率（FDR）校正后的p值进行排序（p值<0.05的位点以蓝色标注）。正相关关系以黄色高亮标注；弥漫型星形细胞瘤中上调表达的基因以绿色高亮标注。若表达探针位于外显子区域，则使用对应全长转录本的探针开展相关性分析（以星号*标注）。（XLSX格式，文件大小85 kb）