Supporting data for "Role of Proprioception in the Development and Progression of Adolescent Idiopathic Scoliosis"

This thesis investigates the relationship between the development of adolescent idiopathic scoliosis (AIS) and impaired proprioception. Findings from scoping and systematic reviews revealed a connection between gene mutations related to proprioception and the onset of idiopathic scoliosis, and confirmed that scoliotic adolescents exhibit proprioceptive deficits (PD). Despite existing gaps in knowledge, we developed a spinal proprioception assessment tool for scoliosis and established normative values from healthy individuals, allowing for clinical diagnosis of PD in our patient cohort. The research highlighted that PD could be a clinical phenotype resulting from the multifactorial nature of AIS and is related to both curve initiation and progression.

本论文探究青少年特发性脊柱侧凸（adolescent idiopathic scoliosis, AIS）的发病与本体感觉受损之间的关联。范围综述与系统综述的研究结果显示，与本体感觉相关的基因突变与特发性脊柱侧凸的发病存在关联，且证实脊柱侧凸青少年存在本体感觉缺陷（proprioceptive deficits, PD）。尽管当前学界仍存在认知空白，本研究开发了一款针对脊柱侧凸的脊柱本体感觉评估工具，并基于健康人群建立了正常参考值，可用于对本研究队列中的患者开展本体感觉缺陷的临床诊断。本研究进一步指出，本体感觉缺陷可能是青少年特发性脊柱侧凸多因素致病机制下的一种临床表型，且与脊柱侧凸的发生及进展均密切相关。