Engineered gut commensal attenuates methylmercury (MeHg) fetal neurotoxicity

The goal of the study is to assess the effects of monocolonization of an engineered demethylating gut microbe towards fetal brain transcriptome in a gestational dietary MeHg exposure murine model. Pregnant mice, monoassociated with engineered or wild-type strain, were subjected to either MeHg-rich (125 ng Hg/g diet; bluefin tuna based), MeHg-modest (2.4 ng Hg/g diet; salmon based), or standard (casein based) diet during pregnancy.