Additional file 1: of Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

Table S1. Kinase inhibitor library screening. A commercial kinase inhibitor library of 274 compounds was tested on 3 different BRAF mutant melanoma cell lines, A375, IGR37 and 501Mel. Each cell line was treated in its sensitive form (parental), and also as 2 resistant derivatives, which were made resistant to either Vemurafenib (XP) or Dabrafenib (GP). Drugs were added at 2 different concentrations, 1 and 10â ÎźM, for 72â h and cell viability was assessed using the PrestoBlue Cell Viability assay. Results are depicted as % viability compared to untreated cells. Each cell line was analyzed at least in duplicate. Inhibitors that were further analyzed and characterized in more detail are marked in red. (XLSX 95 kb)