BAG Montpellier

The BAG of Montpellier gathers researchers from distinct institutes (CBS, IGF, IRIM and LPHI) affiliated to the INSERM, the CNRS and the university of Montpellier.
The CBS is a node of the national infrastructure FRISBI. In this context, it is developping new methodologies for efficient ligand screening by X-ray diffraction. It is also involved in solving the structure of novel therapeutic targets to develop novel drug candidates.
The IGF is involved in characterizing membrane proteins (mainly GPCRs) in order to better understand their functioning for therapeutic application.
The IRIM and LPHI are focusing on several therapeutic targets related to infectious diseases in order to identify and develop novel inhibitors.
CBS and IGF use SAXS to unravel the organization and behavior of various macromolecular systems in solution.
Finally, we also use cryo-electron microscopy to study some macromolecular assemblies.

蒙彼利埃BAG汇聚了隶属于法国国家健康与医学研究院（INSERM）、法国国家科学研究中心（CNRS）及蒙彼利埃大学的多家研究所（CBS、IGF、IRIM和LPHI）的研究人员。
CBS是国家基础设施FRISBI的一个节点。在此背景下，该机构正开发基于X射线衍射的高效配体筛选新方法，同时参与解析新型治疗靶点的结构，以助力候选新药的研发。
IGF致力于膜蛋白（主要为G蛋白偶联受体，GPCRs）的表征研究，以期深入理解其功能机制，为治疗应用提供依据。
IRIM与LPHI则聚焦于传染病相关的多个治疗靶点，旨在发现并开发新型抑制剂。
CBS与IGF还利用小角X射线散射（SAXS）技术解析溶液中各类大分子系统的组织架构与行为特性。
此外，我们亦采用冷冻电子显微镜（cryo-electron microscopy）技术研究部分大分子组装体。