Honey bee virus causes context-dependent changes in host social behavior

Anthropogenic changes create evolutionarily novel environments that present opportunities for emerging diseases, potentially changing the balance between host and pathogen. Honey bees provide essential pollination services, but intensification and globalization of honey bee management has coincided with increased pathogen pressure, primarily due to a parasitic mite/virus complex. Here, we investigated how honey bee individual and social phenotypes are altered by a virus of concern, Israeli acute paralysis virus (IAPV). Using automated and manual behavioral monitoring of IAPV-inoculated individuals, we find evidence for pathogen manipulation of worker behavior by IAPV, and reveal that this effect depends on social context; i.e., within vs between colony interactions. Experimental inoculation reduced social contacts between honey bee colony members, suggesting an adaptive host social immune response to diminish transmission. Parallel analyses with dsRNA-immunostimulated bees revealed thes...

人为活动引发的环境变化创造了进化上全新的生态环境，为新兴疾病提供了滋生契机，有可能改变宿主与病原体间的动态平衡。蜜蜂可提供至关重要的授粉服务，但蜂群管理的集约化与全球化进程，与病原体压力加剧同步发生，这主要源于寄生螨与病毒复合病原体系。本研究聚焦于受关注的病毒——以色列急性麻痹病毒（Israeli acute paralysis virus, IAPV），探究其如何改变蜜蜂的个体与社会表型。通过对IAPV接种个体开展自动化与人工行为监测，我们发现该病毒可操纵工蜂行为，并揭示该效应依赖于社会背景：即蜂群内部与跨蜂群的互动存在差异。实验性病毒接种降低了蜜蜂蜂群成员间的社会接触频次，这提示宿主产生了适应性的社会免疫应答，以减少病毒传播。对经双链RNA（double-stranded RNA, dsRNA）免疫刺激的蜜蜂开展的平行分析显示……