Metagenome-assembled genome catalog obtained using stool metagenomes of melanoma patients

Stool metagenomes from seven published studies were used for obtained of metagenome-assembled genome catalog [Frankel et al., 2017; Gopalakrishnan et al., 2018; Matson et al., 2018; Baruch et al., 2021; Davar et al., 2021; Spencer et al., 2021; Lee et al., 2022].References:1) Frankel, Arthur E., et al. "Metagenomic shotgun sequencing and unbiased metabolomic profiling identify specific human gut microbiota and metabolites associated with immune checkpoint therapy efficacy in melanoma patients." Neoplasia 19.10 (2017): 848-855.2) Gopalakrishnan, Vancheswaran, et al. "Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients." Science 359.6371 (2018): 97-103.3) Matson, Vyara, et al. "The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients." <i>Science</i> 359.6371 (2018): 104-108.4) Baruch, Erez N., et al. "Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients." Science 371.6529 (2021): 602-609.5) Davar, Diwakar, et al. "Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients." Science 371.6529 (2021): 595-602.6) Lee, Karla A., et al. "Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma." Nature Medicine 28.3 (2022): 535-544.7) Spencer, Christine N., et al. "Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response." Science 374.6575 (2021): 1632-1640.

本研究采用已发表的7项研究的粪便宏基因组数据，用于构建宏基因组组装基因组（metagenome-assembled genome, MAG）目录[Frankel et al., 2017; Gopalakrishnan et al., 2018; Matson et al., 2018; Baruch et al., 2021; Davar et al., 2021; Spencer et al., 2021; Lee et al., 2022]。参考文献：1) Frankel, Arthur E., 等. "宏基因组鸟枪测序与无偏代谢组学表征鉴定黑色素瘤患者免疫检查点治疗疗效相关的特定肠道菌群与代谢物"，《Neoplasia》，2017年，第19卷第10期：848-855。2) Gopalakrishnan, Vancheswaran, 等. "肠道菌群调控黑色素瘤患者抗PD-1免疫治疗应答"，《Science》，2018年，第359卷第6371期：97-103。3) Matson, Vyara, 等. "共生菌群与转移性黑色素瘤患者抗PD-1治疗疗效相关"，《Science》，2018年，第359卷第6371期：104-108。4) Baruch, Erez N., 等. "粪便菌群移植可改善免疫治疗难治性黑色素瘤患者的应答"，《Science》，2021年，第371卷第6529期：602-609。5) Davar, Diwakar, 等. "粪便菌群移植可克服黑色素瘤患者对抗PD-1治疗的耐药性"，《Science》，2021年，第371卷第6529期：595-602。6) Lee, Karla A., 等. "跨队列肠道菌群与晚期黑色素瘤患者免疫检查点抑制剂应答的关联分析"，《Nature Medicine》，2022年，第28卷第3期：535-544。7) Spencer, Christine N., 等. "膳食纤维与益生菌影响肠道菌群及黑色素瘤免疫治疗应答"，《Science》，2021年，第374卷第6575期：1632-1640。