Effect of the celexoxib in microscopic changes of the esophageal mucosal of rats induced by esofagojejunostomy

OBJECTIVE: To evaluate the protective effect of celecoxib in the esophageal mucosa in rats undergoing esofagojejunostomy.METHODS: Sixty male Wistar rats from the vivarium of the University of Health Sciences of Alagoas were used for the experiment. The animals were divided into four groups: Group I, 15 rats undergoing esofagojejunostomy with the use of celecoxib postoperatively; Group II, 15 rats undergoing esofagojejunostomy without the use of celecoxib; Group III, 15 rats undergoing celiotomy with bowel manipulation; and Group IV, 15 rats without surgery and using celecoxib. The observation period was 90 days. After the death of the animals, the distal segment of the esophagus was resected and sent for microscopic analysis.RESULTS: esofagojejunostomy caused macroscopic and microscopic esophagitis. Esophagitis was equal in both groups I and II. In groups III and IV esophageal lesions were not developed.CONCLUSIONS: celecoxib had neither protective nor inducing effect on esophagitis, but had a protective effect on dysplasia of the animals of group I.

研究目的：评估塞来昔布（celecoxib）对接受食管空肠吻合术（esofagojejunostomy）的大鼠食管黏膜的保护作用。
实验方法：本研究使用阿拉戈斯健康科学大学动物房饲养的60只雄性Wistar大鼠，将其分为四组：I组为15只术后给予塞来昔布的食管空肠吻合术大鼠；II组为15只未给予塞来昔布的食管空肠吻合术大鼠；III组为15只仅行剖腹术（celiotomy）并实施肠管操作的大鼠；IV组为15只未接受手术且给予塞来昔布的大鼠。实验观察周期为90天，待动物处死后，切除其食管远端节段并送检行显微镜分析。
实验结果：食管空肠吻合术可引发肉眼及镜下食管炎，I组与II组的食管炎程度无显著差异；III组与IV组未出现食管病变。
研究结论：塞来昔布对食管炎既无保护作用，也无诱导作用，但可对I组大鼠的食管异型增生（dysplasia）起到保护作用。