Controlled Self-Assembly of Multiple Diastereomeric Macrocyclic Boronic Esters Composed of Two Chiral Units

Controlled construction of four out of five diastereomers
of macrocyclic
boronic ester was achieved in high yield by utilizing the self-assembly
of two chiral components with the proper choice of reaction conditions.
Three diastereomers could be constructed as enantiopure forms by properly
changing the chirality combination between the two building blocks.
Furthermore, the methodology could be applicable to the three-component
self-assembly of enantiopure macrocyclic boronic esters having two
different diboronic acid moieties.