Nodular melanoma - Male, 74 - Tissue image [5300730025864381]

This is the histopathological image of SKIN tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format. The detailed information about the patient, sample, and diagnosis are as follows: Patient:Age: 74Clinical description: 1,1 x 1,1 x 0,3 cm brown ulcerated lesion of skin of face.Gender: MaleDiagnosis:Classification: ICD-O_3.2Classification code: NEVI AND MELANOMASDiagnosis: Nodular melanomaResult of the histopathological examination: Melanoma of skin (nodular type): SOX-10+, S100+, Melan A-, CKAE1/AE3-, EMA-, Ki-67 80%. Epithelioid cells, ulceration is present, mitotic index: 19 mitoses/1mm2, TILs-NON-BRISK, Clark-IV, Breslow- 2,5 mm, pT3b. Regression is present. Complete excision.Sample:Material: FFPECollecting method: Excision of lesionsTopography: SKINOrgan: SKINTissue: Skin of faceType of staining: positive/IHCStaining: Not applicableAntibody: CK PAN (AE1/AE3)Technology:Equipment: Pannoramic 1000Lens: 20xOrganization:Source: Medical University Gdańsk

本数据集包含格但斯克医科大学（Medical University Gdańsk）采集并存入ZMDL-GUMED的皮肤组织样本病理组织学图像。该样本图像采用Pannoramic 1000切片扫描仪（放大倍数20倍）采集，并以DICOM格式存储。

患者、样本及诊断的详细信息如下：
患者：年龄74岁，男性；临床特征：面部皮肤可见尺寸为1.1×1.1×0.3 cm的棕色溃疡性病变。
诊断分类：依据ICD-O_3.2标准，分类编码为NEVI AND MELANOMAS（痣与黑色素瘤），具体诊断为结节性黑色素瘤。
病理组织学检查结果：皮肤结节型黑色素瘤，免疫组化标记结果为SOX-10阳性、S100阳性、Melan A阴性、CKAE1/AE3阴性、EMA阴性、Ki-67增殖指数80%。镜下可见上皮样细胞及溃疡形成，核分裂象计数为19个/1mm²，肿瘤浸润淋巴细胞（Tumor-Infiltrating Lymphocytes, TILs）为非高危型（NON-BRISK），Clark分级为IV级，Breslow厚度为2.5 mm，pT3b分期，伴肿瘤退行性变，病变已完整切除。

样本信息：样本材质为福尔马林固定石蜡包埋（Formalin-Fixed Paraffin-Embedded, FFPE）组织；采集方式为病变切除术；取材部位为面部皮肤；染色类型为免疫组化（Immunohistochemistry, IHC）阳性对照，未应用特异性染色；所用抗体为CK PAN（AE1/AE3）；扫描设备为Pannoramic 1000；镜头放大倍数为20x；来源机构为格但斯克医科大学（Medical University Gdańsk）。