Additional file 5 of In search of the Aplysia immunome: an in silico study

Additional file 5: Supplemental File SFile5. Target genes and requisite InterPro domains. The list of genes of interest and their requisite domains used to identify putative immune genes in Aplysia californica. The list combines data from previous mollusk immunome in silico studies in Pacific oyster Crassostrea gigas [3] and pond snail Lymanaea stagnalis [10] and reviews of immune-associated genes in vertebrates, mollusks, and arthropods [2, 4, 5, 9, 29–31, 33, 47, 54, 60, 62–64, 68, 88, 98, 117, 121–129]. Genes are categorized according to their broad immune function and more specific gene family. Required InterPro domains are listed as strict (as appears in human) or relaxed (required domains as seen in non-human or non-mammalian systems). Human UNIPROT identifiers of example genes are listed and were futher used in OrthFinder homology search comparisons. For some genes that exist only in ecdysozoans, the Drosophila UNIPROT identifier is also given. The DOI and link to the source literature is also provided.

附加文件5：补充文件SFile5。本文件包含靶基因与必需InterPro（InterPro）结构域，收录了用于鉴定加州海兔（Aplysia californica）潜在免疫基因的目标基因列表及其必需结构域。该列表整合了此前针对太平洋牡蛎（Crassostrea gigas）[3]和静水椎实螺（Lymnaea stagnalis，原文笔误为Lymanaea stagnalis）的软体动物免疫组虚拟研究数据，以及针对脊椎动物、软体动物与节肢动物（arthropods）免疫相关基因的综述文献[2, 4, 5, 9, 29–31, 33, 47, 54, 60, 62–64, 68, 88, 98, 117, 121–129]。研究人员根据基因的广谱免疫功能及更细分的基因家族对其进行分类。所需的InterPro结构域分为严格型（与人类中的标注一致）与宽松型（匹配非人类或非哺乳动物系统中的结构域要求）。文中列出了示例基因的人类UniProt（UniProt）标识符，并将其进一步用于OrthFinder（OrthFinder）同源性搜索比对。对于仅存在于蜕皮动物总门（ecdysozoans）中的部分基因，还补充给出了果蝇（Drosophila）的UniProt标识符。此外，本文还提供了相关来源文献的DOI及链接。