HEMODINAMIC EFFECTS OF CONTINUOUS RATE INFUSION OF BUTORPHANOL IN PROPOFOL-ANESTHETIZED DOGS

Abstract The aim of this study was to evaluate the hemodynamic effects of the total intravenous anesthesia with propofol and butorphanol in dogs. For that purpose, twenty adult healthy crossbred dogs were used. The animals were equally allocated into two groups (PG and BG) and induced to the anesthesia with intravenous propofol (10 mg/kg). After orotracheal intubation, controlled ventilation was instituted with 60% oxygen and flow of 30 mL/kg/min in a closed system, with controlled volume. The anesthetic maintenance was accomplished with propofol (0.6 mg/kg/min). The butorphanol group (BG) received, butorphanol 0.1 mg/kg IV, followed by continuous infusion (40 μg/kg/h). The placebo group (PG) received only NaCl 0.9% in bolus, followed by venous infusion, in identical volume of the BG. Baseline hemodynamic measurements were performed before opioid or saline administration (M0) and immediately after, every 15 minutes (M15 to M75). Administration of butorphanol resulted in decrease of total peripheric resistance (TPR), arterial pressures (SAP, DAP, MAP) and cardiac output (CO), without clinical relevance. The results allow us to conclude that association provides safe anesthesia for patients with ventilatory support.

摘要 本研究旨在评估异丙酚（propofol）联合布托啡诺（butorphanol）实施全静脉麻醉对犬的血流动力学影响。为此，选取20只健康成年杂交犬作为实验对象。将实验动物随机均分为两组（PG组与BG组），均以异丙酚静脉推注（10 mg/kg）诱导麻醉。经口气管插管后，采用闭合系统行容量控制通气，吸入氧浓度为60%，通气流量为30 mL/kg/min。麻醉维持采用异丙酚持续输注（0.6 mg/kg/min）。布托啡诺组（BG组）先静脉推注布托啡诺0.1 mg/kg，随后以40 μg/kg/h的速率持续输注；安慰剂组（PG组）则以与BG组相同体积的0.9%氯化钠溶液先行推注，后续予以同等速率的静脉输注。分别在阿片类药物或生理盐水给药前（M0）、给药后即刻及每隔15分钟（M15至M75）进行基础血流动力学指标监测。结果显示，给予布托啡诺可导致总外周阻力（total peripheral resistance, TPR）、动脉血压[收缩压（systolic arterial pressure, SAP）、舒张压（diastolic arterial pressure, DAP）、平均动脉压（mean arterial pressure, MAP）]及心输出量（cardiac output, CO）降低，但该变化不具有临床相关性。综上，本研究结果表明，该联合麻醉方案可为接受通气支持的犬只提供安全的麻醉效果。