Crystal structure of Bcl-2 D103Y in complex with sonrotoclax
收藏Protein Data Bank Japan2024-05-15 更新2026-04-19 收录
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Crystal structure of Bcl-2 D103Y in complex with sonrotoclax Descriptor: Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide Authors: Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. Deposit date: 2022-12-10 Release date: 2024-01-17 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143, 2024
创建时间：
2022-12-10
