Expression data from mouse intestinal organoids II
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE76848
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资源简介：
APC inactivation is the early process in the tumorigenesis of colorectal cancer. We established organoid cultures from intestines of genetically modifeid mice harboring Apcfl/fl, Tacc3wt/wt or Apcfl/fl, Tacc3fl/fll and R26CreERT2 allele We used microarrays to determine the alterations in intestinal stem cells in response to Tacc3 disruption. Organoids were treated with 4OHT to induce recombination of APC and Tacc3, and collected at 4 or 6 days after treatment. RNA were extracted and hybridization on Affymetrix microarrays.
创建时间：
2019-02-11
