Synthesis of novel mesoporous silicate molecular sieves by Aerosol-assisted method for loading and release of drug

The novel mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by aerosol-assisted method for loading and release of ibuprofen. The synthesized samples were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and N2 adsorption-desorption isotherms. The drug ibuprofen was applied as a model drug to investigate the drug release behavior by UV spectrophotometry measurements. The investigation results demonstrate that mesoporous silicate molecular sieves by aerosol-assisted method are spherical with the core-shell structure. As the drug carrier, it has good structural stability and can achieve drug controlled release which is expected. Therefore, the aerosol-assisted synthesis method provides a new idea for the synthesis of sustained-release drug carriers.

本研究以聚醚F127为模板剂，通过气溶胶辅助法合成新型介孔硅酸盐分子筛（mesoporous silicate molecular sieves），用于布洛芬的负载与释放。采用扫描电子显微镜（scanning electron microscopy, SEM）、透射电子显微镜（transmission electron microscopy, TEM）、X射线衍射（X-ray diffraction, XRD）以及N₂吸附-脱附等温线对合成样品进行了表征。以布洛芬作为模型药物，通过紫外分光光度法考察其药物释放行为。研究结果表明，采用气溶胶辅助法合成的介孔硅酸盐分子筛呈球形且具有核壳结构。该材料作为药物载体具备良好的结构稳定性，可实现预期的药物控释效果。因此，气溶胶辅助合成法为缓释药物载体的合成提供了全新思路。