Whole blood spatial gene regulatory network

This dataset consists of spatially constrained eQTLs. Briefly, all common single nucleotide polymorphisms (SNPs; MAF >0.05) present in whole blood were obtained from GTEx v8 and used to interrogate prepared Hi-C libraries. This allowed for the identification of SNP-gene pairs that are physically interacting. The identified SNP-gene pairs were then tested for eQTL effects by integrating eQTL data from GTEx v8. eQTLs with an adjusted p-value ≤0.05 were selected as being significant (Benjamini-Hochberg).

本数据集包含空间约束的表达数量性状位点（expression quantitative trait loci, eQTLs）。简言之，我们从GTEx v8版本中获取了全血中存在的所有常见单核苷酸多态性（single nucleotide polymorphisms, SNPs，次要等位基因频率（minor allele frequency, MAF）>0.05），并将其用于解析已制备的高通量染色体构象捕获（High-throughput Chromosome Conformation Capture, Hi-C）文库，借此可鉴定出存在物理相互作用的SNP-基因对。随后，我们整合GTEx v8版本的eQTL数据，对已鉴定的SNP-基因对开展eQTL效应检测；经Benjamini-Hochberg法校正后，P值≤0.05的eQTLs被判定为具有统计学显著性。