Molecular profiles of the hepatic response to caloric restriction in rhesus monkeys

This dataset contains data derived from liver biopsy tissue collected at two time points from young adult rhesus macaques (Macaca mulatta). The animals were an all-male subset of a larger study begun at the University of Wisconsin-Madison in 1989. The study was designed to examine the consequences of caloric restriction (CR) on a non-humane primate model organism. This data comes from male monkeys on control and CR diets at the time they were enrolled in the study, and after two years of study diet. This was combined with other molecular profiling techniques (RNA-Seq, shotgun lipidomics, NMR metabolomics) to examine the longitudinal, molecular changes accompanying short-term CR.

本数据集收录了从两只时间点采集的成年恒河猴（Macaca mulatta）肝活检组织数据。这些动物是始于1989年于威斯康星大学麦迪逊分校的一项更大规模研究中的全部雄性子集。该研究旨在探究卡路里限制（CR）对非人灵长类模式生物的影响。数据来源于研究招募时处于控制组和卡路里限制饮食组的雄性猴子，以及经过两年研究饮食后的猴子。这些数据与其它分子分析技术（RNA测序、全谱脂质组学、核磁共振代谢组学）相结合，以探究伴随短期卡路里限制的纵向分子变化。