Biological chromodynamics: a general method for measuring protein occupancy across the genome by calibrating ChIP-seq

Sequencing DNA fragments associated with proteins following in vivo cross-linking with formaldehyde (known as ChIP-seq) has been used extensively to describe the distribution of proteins across genomes通过甲醛进行体内交联后，测序与蛋白质结合的DNA片段的技术，即染色质免疫共沉淀测序（ChIP-seq），已被广泛用于解析蛋白质在全基因组范围内的分布特征。