Eliminating malaria transmission requires targeting immature and mature gametocytes through lipoidal uptake of antimalarials

Supplementary data for meta-analysis of antimalarial compounds with activity against asexual blood stage parasites, immature and mature gametocytes. Additional validation of activity profiles by parallel evaluation of 80 MMV compounds. Associated drug target expression (transcriptome and proteome) data and physicochemical properties of antimalarial candidates.

本数据集为针对可作用于无性血液阶段疟原虫、未成熟及成熟配子体的抗疟化合物所开展的荟萃分析（meta-analysis）的补充数据。通过对80种MMV化合物进行平行评价，额外验证了其活性谱特征。同时附带相关药物靶点表达（转录组（transcriptome）与蛋白质组（proteome））数据以及抗疟候选药物的理化性质。