Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x]

A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined.

本研究成功合成并表征了一种以钇（Y）离子与钾（K）离子作为节点、中位四(4-羧基苯基)卟啉（meso-tetra(4-carboxyphenyl)porphyrin）作为连接配体构建的新型杂金属卟啉框架（heterometallic metal-porphyrinic framework, MPFs）。单晶X射线衍射分析表明，该配合物1呈现出卟啉配体构成的双层架构，此类结构在MPFs中较为罕见。此外，本研究进一步测定了配合物1对三株人类乳腺癌细胞系（BT474、SKBr-3及ZR-75-30）的体外抗癌活性。