Solution NMR structures of hTERT DNA G-quadruplexes (G4s) in complex with small molecule CPT-11

Solution NMR structures of hTERT DNA G-quadruplexes (G4s) in complex with small molecule CPT-11 Descriptor: (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE, DNA (5'-D(*AP*AP*TP*GP*GP*GP*AP*GP*GP*GP*TP*CP*TP*GP*GP*GP*AP*GP*GP*GP*CP*C)-3'), POTASSIUM ION Authors: Zeng, L. Deposit date: 2025-06-02 Release date: 2026-02-11 Last modified: 2026-05-06 Method: SOLUTION NMR Cite: Dual targeting of topoisomerase I and DNA G-quadruplexes enhances senescence and chemosensitivity in colorectal cancer. Commun Biol, 9, 2026