Supplementary Material for: Lung Function of Infants with Congenital Lung Lesions in the First Year of Life

<b><i>Background:</i></b> Several studies have evaluated short-term neonatal outcome in infants with congenital lung lesions (CLL) but clinical course and lung function in the longer term have not yet been documented. We hypothesized that clinical course and lung function would be negatively affected by surgical resection. <b><i>Objective:</i></b> To evaluate respiratory symptoms and lung function longitudinally in the first year of life in infants with CLL, and to analyse differences herein between infants managed by observation only and infants whose affected lung parts were resected. <b><i>Methods:</i></b> We evaluated respiratory symptoms and lung function at 6 and 12 months in 30 patients with CLL. Functional residual capacity (FRC_p) and maximal expiratory flow at functional residual capacity (V′_maxfrc) were measured with body plethysmography. SD scores were calculated for V′_maxfrc. <b><i>Results:</i></b> Prevalence of respiratory symptoms did not differ between the groups. Mean FRC_p (95% CI) was 25.3 (23.3–27.3) in the group managed by observation versus 27.3 (25.1–29.6) in the group managed by surgery (p = 0.149). Mean (95% CI) SDS V′_maxfrc was –1.45 (–1.84 to –1.06) versus –1.41 (–1.90 to –0.91) (p = 0.892). Lung function did not change significantly over the 6-month period. <b><i>Conclusion:</i></b> Surgical resection did not seem to have negatively affected the clinical course and lung function. We recommend pulmonary follow-up of all CLL patients into adulthood to further identify any long-term effects of CLL and observation or surgery.

**背景：** 已有多项研究评估了先天性肺病变（congenital lung lesions, CLL）患儿的短期新生儿结局，但此类患儿的长期临床病程与肺功能尚未有相关文献记录。我们推测手术切除治疗会对患儿的临床病程及肺功能产生负面影响。
**研究目的：** 纵向评估先天性肺病变婴儿出生后第一年内的呼吸系统症状与肺功能情况，并分析仅接受观察组与接受病变肺组织切除术患儿之间的差异。
**研究方法：** 本研究对30例先天性肺病变患儿分别于出生后6个月和12个月时评估其呼吸系统症状与肺功能。采用体积描记法（body plethysmography）测量功能残气量（functional residual capacity, FRCp）及功能残气量处的最大呼气流速（maximal expiratory flow at functional residual capacity, V′maxfrc），并计算V′maxfrc的标准差评分（SD scores）。
**研究结果：** 两组患儿呼吸系统症状的患病率无显著差异。观察组的平均FRCp（95%置信区间）为25.3（23.3~27.3），手术组为27.3（25.1~29.6）（p=0.149）。两组的平均（95%置信区间）V′maxfrc标准差评分分别为-1.45（-1.84~-1.06）与-1.41（-1.90~-0.91）（p=0.892）。6个月随访期内，患儿肺功能无显著变化。
**研究结论：** 手术切除似乎并未对先天性肺病变患儿的临床病程与肺功能产生负面影响。我们建议对所有先天性肺病变患者进行直至成年的肺部随访，以进一步明确先天性肺病变本身以及观察或手术治疗的长期影响。