Omics-Lethal Human Viruses, West Nile Experiment WGCN003

The purpose of this experiment was to evaluate the host response to wild-type West Nile virus infectious clone (WNV-NY99 clone 382) and mutant (WNVE218A) virus infection. Sample data was obtained from mouse granule cell neurons for mRNA and miRNA expression analysis. See Experiment WGCN002 for corresponding independent biological replicate study. Secondary host-associated viral dataset downloads contain one or more statistically processed (normalization data transformation) quantitative dataset collections resulting in qualitative expression analyses of primary host-pathogen experimental study designs. Transcriptomics dataset downloads have a direct relationship to a primary sample submission corresponding to a specific West Nile virus infection.

本实验旨在评估宿主对野生型西尼罗河病毒（West Nile Virus, WNV）感染性克隆（WNV-NY99克隆382）及突变型（WNVE218A）病毒感染的应答反应。样本数据采集自小鼠颗粒细胞神经元，用于信使RNA（mRNA）与微小RNA（miRNA）的表达分析。相关独立生物学重复研究详见实验WGCN002。二级宿主相关病毒数据集下载资源包含一个或多个经统计处理（含标准化数据变换）的定量数据集集合，可用于开展原宿主-病原体实验研究设计的定性表达分析。转录组学（transcriptomics）数据集下载与对应特定西尼罗河病毒感染的原始样本提交存在直接关联。