ITABAG: 3D structures of macromolecules related to human health

The ITABAG includes structural biologists from Universities, National Research Council and Hospital research centres in Italy. The laboratories apply various diffraction methods to study the structure-function relationships in various macromolecules. A unifying factor for the vast majority of the macromolecules under study is that they are related to human health, either directly, being human proteins involved in some disease, or indirectly, as proteins expressed by human pathogens and validated as potential pharmacological targets. Other projects investigate basic chemical processes, such as crystal growth and polymer association and formation of nanostructures.

ITABAG汇集了来自意大利高校、国家研究委员会及医院研究中心的结构生物学家。其所属实验室依托多种衍射技术，研究各类大分子的结构-功能关联。该团队所研究的绝大多数大分子均与人类健康密切相关：一类是直接相关的人类蛋白质，参与特定疾病的发生发展过程；另一类则间接相关，即由人类病原体表达并被验证为潜在药物靶点的蛋白质。此外，另有部分项目围绕基础化学过程展开研究，涵盖晶体生长、聚合物缔合及纳米结构的形成等方向。