Monitoring the Effect of Transdermal Drug Delivery Patches on the Skin using Terahertz Sensing

THz measurements of the skin of 5 subjects before and after the application of partially and fully occlusive patches for transdermal drug delivery. The patches were applied for 24 hours, the skin regions were then measured immediately after patch removal and 30 minutes and 4hours after the patches were removed. In addition to changing the backing material of the patch we also varied the propylene glycol content of the patch to observe the effects on the skin.<br>Regions on the left arm were treated with the partially occlusive patches while the right arm was treated with fully occlusive patches. Regions are numbered 1-4 where 1=3% propylene glycol, 2= control, 3= 6% propylene glycol, 4=0% propylene glycol.<br>The txt files are structured so the top two rows are the voltages measured by the pressure sensors at each time point. The first column is the time in ps and the following columns are the measured THz pulses for each of the 240 measurements, acquired every 0.25 seconds.

本数据集包含5名受试者在使用透皮给药用半封闭贴剂与全封闭贴剂前后的皮肤太赫兹（THz）检测数据。贴剂敷用时长为24小时，分别在贴剂移除即刻、移除后30分钟及移除后4小时对相应皮肤区域开展检测。此外，研究团队除调整贴剂的背衬材料外，还通过改变贴剂中的丙二醇含量，以观测其对皮肤产生的影响。
受试者左臂区域采用半封闭贴剂处理，右臂区域则采用全封闭贴剂处理。皮肤区域编号为1至4，其中1对应3%丙二醇含量组、2为空白对照组、3对应6%丙二醇含量组、4对应0%丙二醇含量组。
文本文件的结构规范如下：前两行为各时间点压力传感器采集的电压信号；第一列为以皮秒（ps）为单位的时间坐标，后续各列则为每0.25秒采集一次的240次单次检测对应的太赫兹脉冲测量数据。