Total Synthesis and Absolute Configuration Determination of the α‑Glycosidase Inhibitor (3S,4R)‑6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl (Z)‑2-Methylbut-2-enoate from Ageratina grandifolia

Herein, we report the first total synthesis of α-glycosidase inhibitor (3R, 4S)-6-acetyl-3-hydroxy-2,2-dimethylchroman-4-yl (Z)-2-methylbut-2-enoate as well as its enantiomer. Our synthesis confirms the chromane structure separately proposed by Navarro-Vazquez and Mata, on the basis of DFT computations. Furthermore, our synthesis allowed us to determine the absolute configuration of the natural compound as (3S, 4R) and not (3R, 4S).