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Molecular basis for targeted therapy in T-cell lymphoma/leukemia.

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA349968
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T-cell lymphoma (TCL) is a collection of aggressive disorders with unfavorable outcome, where the introduction of targeted treatment is still in a preliminary phase. To gain deeper insights into deregulated mechanisms promoting this disease, we analyzed a panel of 34 representative T-cell lymphoma cells looking for predictive markers of response to targeted therapy. To do so, a combination of targeted sequencing was performed alongside with the expression of specific biomarkers corresponding to potentially activated survival pathways.
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2016-10-21
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