WilliamsAT_prePMID_HRI.tsv.gz

These summary statistics were derived from a genome-wide association
study of hospitalised respiratory infections in UK Biobank.

The file includes data for 52,488,101 unique genetic
variants and contains the following columns: variant_id, chromosome,
base_pair_location (GRCh37), effect_allele, other_allele, effect_allele_frequency,
beta (log-odds ratio), standard_error, p_value.

This study used anonymised data from UK Biobank, a cohort of
500,000 volunteer participants aged between 40 and 69 years recruited from
across the United Kingdom (UK) between 2006 and 2010. This research was
conducted under approved UK Biobank data applications 648 and 4892. Individuals
included in our analysis if (1) they had genome-wide imputed genetic data; (2) they
had complete information for age (at recruitment), sex and smoking status (at
recruitment); (3) they had no 2nd degree or closer relative (defined
by a kinship estimate >0.0884 from the KING software, provided by UK Biobank),
and (4) they were of European ancestry based on k­-means clustering of the
first two principal components of ancestry. Overall, we included 19,459 hospitalised
respiratory infection cases and 101,438 healthy controls in our study.

Genotyping was undertaken using the Affymetrix Axiom UK
BiLEVE and UK Biobank arrays. Genotype imputation was conducted using the
Haplotype Reference Consortium (HRC) panel and the merged 1000 Genomes phase 3
and UK10K panels. Imputed genotypes with a minor allele count >20 and an
imputation quality score >0.5 were tested for association with hospitalised
respiratory infections.

PLINK 2.0 (https://www.cog-genomics.org/plink/2.0/)
was used to conduct the genome-wide association study. We assessed autosomal
variant associations under an additive genetic model adjusted for age (at
recruitment), age2, genotyping array, sex, smoking status and the
first ten principal components of ancestry. We analysed variant dosages in
order to account for genotype uncertainty.

Further details and results are described in the manuscript:
Genome-wide association study of susceptibility to hospitalised respiratory
infections. Wellcome Open Research.