Structure of RET kinase domain bound to inhibitor JB-48
收藏Protein Data Bank Japan2024-10-23 更新2026-04-19 收录
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Structure of RET kinase domain bound to inhibitor JB-48 Descriptor: 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{H}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{N}-(3-fluorophenyl)ethanamide, FORMIC ACID, Proto-oncogene tyrosine-protein kinase receptor Ret Authors: Briggs, D.C, McDonald, N.Q. Deposit date: 2021-03-24 Release date: 2022-02-09 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose. J.Med.Chem., 65, 2022
创建时间：
2021-03-24
