Monocyte responses associate with MAC lung disease. Monocyte responses associate with MAC lung disease

To understand nontuberculous mycobacterial (NTM) pathogenesis, we evaluated immune responses to Mycobacterium avium (Mav) in asymptomatic individuals with a previous history of M. avium complex lung disease (MACDZ). We analyzed global gene expression in paired Mav-infected and uninfected peripheral blood monocytes from 17 MACDZ and 17 healthy controls. Overall design: Comparative gene expression profiling analysis of RNA-seq data for peripheral blood monocytes infected with M. avium or media controls.