Processed single-cell ATAC-seq data of CD4+ T cell subsets from skin and blood of healthy human donors

This record contains a Seurat object of scATAC-seq data of human CD4+ T cell subsets from skin and blood (healthy donors).The following cell types are included:Blood naive (CD45RA+) Tconv cellsBlood naive (CD45RA+) Treg cellsBlood CCR8+ Treg cellsSkin Tconv cellsSkin Treg cells The object is saved in RDS format and can be used with the programming language "R" using the readRDS() function.This data was used in the following publication:Beumer. N. et al.: DNA hypomethylation traits define human regulatory T cells in cutaneous tissue and identify their blood recirculating counterparts. Nature Immunology (2025), https://doi.org/10.1038/s41590-025-02210-xIt is based on a data set generated by Malte Simon and used in the following publication:Delacher, M. et al.: Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity 54, 702-720 (2021), https://doi.org/10.1016/j.immuni.2021.03.007 When using this data set, please cite the two aforementioned publications. Corresponding raw sequencing data is deposited in the European Genome Phenome Archive (EGA; accession number: EGAD00001006779).