Bulk RNA-Seq comparing pancreatic acinar cells based on their expression levels of KRAS protein (Citrine-KRAS fusion)

We developped new mouse models to detect endogenous KRAS protein expression pattern via a Citrine-KRAS (Cit-K) fusion construction Using our mouse model we sorted pancreatic acinar cells based on their expression levels of Cit-K. We compared the transcriptiome of Cit-K-Pos (KRAS-Pos) vs Cit-K-Neg/Low (KRAS-Neg/Low) cells