Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0516
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Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZL0516 Descriptor: 1,2-ETHANEDIOL, 2-{4-[(2R)-2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]-3,5-dimethylphenyl}-5,7-dimethoxy-4H-1-benzopyran-4-one, Bromodomain-containing protein 4 Authors: Leonard, P.G, Joseph, S. Deposit date: 2019-11-05 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J.Med.Chem., 63, 2020
创建时间：
2019-11-05
