Effect of glycemic index on obesity control

Objective Evaluate the effect of glycemic index (GI) on biochemical parameters, food intake, energy metabolism, anthropometric measures and body composition in overweight subjects.Materials and methods Simple blind study, in which nineteen subjects were randomly assigned to consume in the laboratory two daily low GI (n = 10) or high GI (n = 9) meals, for forty-five consecutive days. Habitual food intake was assessed at baseline. Food intake, anthropometric measures and body composition were assessed at each 15 days. Energy metabolism and biochemical parameters were evaluated at baseline and the end of the study.Results Low GI meals increased fat oxidation, and reduced waist circumference and HOMA-IR, while high GI meals increased daily dietary fiber and energy intake compared to baseline. There was a higher reduction on waist circumference and body fat, and a higher increase on postprandial fat oxidation in response to the LGI meals than after high GI meals. High GI meals increased fasting respiratory coefficient compared to baseline and low GI meals.Conclusion The results of the present study showed that the consumption of two daily low GI meals for forty-five consecutive days has a positive effect on obesity control, whereas, the consumption of high GI meals result has the opposite effect. Arch Endocrinol Metab. 2015;59(3):245-51

研究目的：评估血糖指数（glycemic index, GI）对超重受试者的生化指标、食物摄入、能量代谢、人体测量指标及身体成分的影响。
材料与方法：本研究为单盲试验，共纳入19名受试者，将其随机分组，在实验室连续45天每日食用2餐低GI（n=10）或高GI（n=9）膳食。基线阶段评估受试者的习惯性食物摄入情况；每15天开展1次食物摄入、人体测量指标及身体成分检测；能量代谢与生化指标分别于基线及研究结束时完成评估。
研究结果：低GI膳食可提升脂肪氧化率，降低腰围及稳态模型胰岛素抵抗指数（HOMA-IR）；与基线相比，高GI膳食可增加每日膳食纤维摄入量与能量摄入。相较于高GI膳食干预，低GI膳食干预后受试者的腰围、体脂降幅更为显著，餐后脂肪氧化提升幅度更大。高GI膳食较基线及低GI膳食可升高空腹呼吸商。
研究结论：本研究结果显示，连续45天每日食用2餐低GI膳食对肥胖控制具有积极作用，而高GI膳食则产生相反效果。本研究原文刊载于《内分泌代谢档案（Arch Endocrinol Metab）》2015;59(3):245-51