The Israeli BAG

The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

本BAG汇聚了大量首席研究员，其中绝大多数为以色列结构生物学家。其研究主题极为庞杂多元，短篇幅摘要难以全面涵盖其全貌。在此背景下，BAG成员正开展多项前沿研究：调控蛋白质组装的关键参数、不同信号通路中信号传导过程的结构影响，以及蛋白水解反应的热力学机制。此外，团队还推进核糖体研究项目，设计源自密霉素（mycinamycins）家族、具备特异性功能相互作用的新型抗生素，并对比大环内酯类（macrolides）抗生素，深入研究其耐药相关机制；同时解析光系统及其将光能转化为生物能量的分子机制。受当前疫情形势推动，团队正开展多项新冠病毒（COVID-19）相关研究项目；而BAG成员长期以来始终深耕病毒感染与抑制策略研究，涵盖丙型肝炎病毒、虫媒病毒（如登革热病毒、西尼罗河病毒、寨卡病毒、以色列-土耳其脑膜脑炎病毒）、基孔肯雅病毒等多种病原体。