Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma

Background. This present study aimed to assess if clinical, laboratory and MRI were an accurate benchmark in assessing the effectiveness of neoadjuvant chemotherapy in osteosarcoma patients. Methods. This was an observational analytic study with a cross-sectional design. Research subjects were selected using the total sampling method from osteosarcoma patients who underwent neoadjuvant chemotherapy during the period between January 2017– July 2019. Results.Of the 58 patients included in this study, 38 were male and 20 were female aged 5 - 67 years (mean,16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy with CAI regimens and 13 (36.2%) with CA. The tumors were classified as stage IIB in 43 (74.1%) patients and stage III in15 (25.9%) patients. After undergoing neoadjuvant chemotherapy, 4 patients had poor MSTS, 30 patients had fair MSTS, 17  and 7 patients had good and excellent MSTS score, respectively. Spearman’s test revealed no correlation between tumor necrosis after...

背景 本研究旨在评估临床指标、实验室检测结果及磁共振成像（MRI）能否作为评估骨肉瘤患者新辅助化疗疗效的精准参照基准。方法 本研究为采用横断面设计的观察性分析研究。研究对象采用全数抽样法，选取2017年1月至2019年7月期间接受新辅助化疗的骨肉瘤患者。结果 本研究共纳入58例患者，其中男性38例，女性20例，年龄5~67岁，平均年龄16岁。37例（63.8%）患者采用CAI方案行新辅助化疗，13例（36.2%）采用CA方案。肿瘤分期为IIB期者43例（74.1%），III期者15例（25.9%）。接受新辅助化疗后，4例患者肌肉骨骼肿瘤学会（MSTS）评分较差，30例评分一般，17例与7例患者评分分别为良好与优秀。斯皮尔曼检验（Spearman's test）显示，化疗后肿瘤坏死率与……