Cell type distribution in female and male mouse brains / Npy1_GFP_F4_200512

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项目旨在建立一个用于系统描绘雌性和雄性大脑中细胞类型分布和形态的解剖学协作实验室。该实验室将应用实验室开发的标准化的、无偏见的以及高度自动化的方法，对超过80种分子定义的细胞类别及其在雌性和雄性大脑所有区域中的分布和形态进行图谱绘制。此项工作将提供迄今为止对哺乳动物大脑中细胞类型解剖学的最全面描述，为构建一个综合的细胞类型大脑图谱奠定了结构基础。